Bactericides For Helicobacter Pylori
Quickly and sufficiently absorbed from the gastrointestinal tract, but the bioavailability is not more than 50-55% (the effect of the first passage through the liver). Maximum plasma concentration is achieved through 0,5-3,5 hours. Protein binding 95%. The half-life is 0,5-1 hours (with normal liver function) or 3 hours (with chronic liver diseases). Biotransformation in the liver. Metabolites are not active. Excreted by the kidneys as metabolites (72-80%) and through the intestine (18-23%). After a single dose of 20 mg of inhibition of gastric secretion occurs during the first hour, reaching a maximum after 2 hours and lasts about 24 hours. Severity of effect depends on the dose. The ability of parietal cells produce hydrochloric acid is restored within 3-5 days after treatment.
The peculiarity of omeprazole is that after repeated application of increasing absorption of the generic, thus increasing its antisecretory effect.
The injectable form of the drug (the only representative in the pharmaceutical market Loseke Swedish firm Online Pharmacy Without Prescription) is used for quick relief of (in the first 1-2 days) of clinical symptoms of exacerbation kislotozavisimyh diseases of the upper digestive tract, especially those with complicated course.
Especially important is the intravenous Loseke with gastroduodenal hemorrhage occurring as a complication of peptic ulcer, portal hypertension, as well as in stress, steroids, indometatsinovyh (or the use of other ulcerogenic indian drugs) and other acute ulcers. Conducted numerous clinical studies have shown the possibility of such a conservative stop bleeding without surgical intervention. Intravenous form Loseke is also convenient when it is impossible oral dose.
Overdosage
Total for the group, as well as:
” fever
” photosensitization,
” paresthesia,
” interstetsialny nephritis
” alopecia,
” gynecomastia
” impotence,
” breach of taste
” stomatitis,
” candidiasis,
On the part of hematopoiesis: thrombocytopenia, leukopenia, agranulocytosis, pancytopenia.
Interaction
Total for the group, as well as:
” Enhances the effect of coumarins and difenina.
” Slows eliminitsiyu generics metabolized in the liver by microsomal oxidation (warfarin, diazepam, phenytoin).
” Increases (mutually) concentration in the blood of clarithromycin.
Dosage and application
Inside:
In gastric ulcer, duodenal ulcer and reflux esophagitis – 20 mg 1 time a day (if necessary – 40 mg). In duodenal ulcer treatment 2-4 weeks, with a stomach ulcer and reflux esophagitis – 4-8 weeks.
For the prevention of peptic ulcer disease – 20 mg 1 time per day.
In Zollinger-Ellison syndrome: initial dose – 20-60 mg per day, if necessary, up to 120 mg / day (daily dose above 80 mg should be divided into two sessions) for 2-8 weeks. The level of secretion in the stomach must be at nerezetsirovannyh patients up to 10 mM HCl / h, the resected – up to 5 mmol HCl / h
In peptic ulcer caused by Helicobacter pylori, in combination: omeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 mg or omeprazole 20 mg, metronidazole 400 mg, clarithromycin 250 mg 2 times a day for 7 days.
Intravenous:
1 times per day. The substance (40 mg) was dissolved in 100 ml of saline or 5% dextrose solution and injected within 20-30 minutes after dilution. Infusion should be completed in 12 hours, if the solvent – saline solution, and within 6 hours, when dissolved in dextrose. Usually it is sufficient to conduct infusion over 2-5 days, after which the patient can be transferred to oral medication.
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